Thursday, July 18, 2013

Updated Bloodthinners

Here is an updated list with some common blood thinners that you may run into. If you think of any other types of blood thinners, please leave a comment, so I can update the list. In addition, I also added how the blood thinner works in the body, thus causing its effects. If you scroll all the way to the bottom, I have included a picture of the coagulation cascade. This process id very tough and confusing, so i highly recommend that you watch a few youtube(R) videos on the system. I, myself, still don't fully understand the entire cascade system. So, if you find a way that helps you to remember, please leave a comment, or upload your diagram to help others, and myself, understand the system.

-Brand Name (Generic Name)
-How it works

Clopidogrel (Plavix)
-The drug works by irreversibly inhibiting a receptor called P2Y12*, an adenosine diphosphate (ADP), organic compound in metabolism, chemoreceptor on platelet cell membranes

Coumadin (Warfarin)
-Vitamin K antagonist (attaches to a receptor site, but does not cause a response)

Heparin (heparin)
-Regulating the activity of the body's natural antigolaulant molecules (antithrombin III)

Pradaxa (dabigatran)
-PRADAXA is a type of medicine known as a direct thrombin inhibitor
-PRADAXA works by attaching itself to thrombin—the blood’s central clotting agent. This reduces the ability of the thrombin to cause a clot.

Xarelto (rivaroxaban)
-Blocks Factor Xa (FXa)** at a central point in the coagulation cascade, where the extrinsic and intrinsic pathways meet, helping to modulate thrombin generation

-       -Prevents in the formation of platelets
Eliquis (apixaban)
-       -Blocking Factor Xa**, which is a blood clotting factor critical to the blood clotting process.


*P2Y12 is a chemoreceptor for adenosine diphosphate(ADP).

**Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in the blood coagulation cascade. It holds a central position that links the intrinsic and extrinsic pathways to the final common coagulation pathway. Factor Xa converts the prothrombin zymogen to its active form, thrombin.

Intrinsic – contact activation pathway - vessel wall damnage causes activation
Extrinsic – tissue factor pathway 

Coagulation Cascade Diagram 

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